#19: Charlie Sheen’s Problems Led to His Removal From Two and a Half Men (2003)
Charlie Sheen’s behavior contributed to his removal from Two and a Half Men (2003) in 2011, as television’s highest-paid star. Warner Bros. cited problems with his conduct and working with producers. Ashton Kutcher replaced him, and the sitcom continued until 2015, showing a hit series can survive a casting change.

